RG 14620,, 136831-49-7 - Names and Identifiers
RG 14620,, 136831-49-7 - Physico-chemical Properties
Molecular Formula | C14H8Cl2N2
|
Molar Mass | 275.13 |
Density | 1.355±0.06 g/cm3(Predicted) |
Melting Point | 150-151℃ |
Boling Point | 418.2±45.0 °C(Predicted) |
Solubility | DMSO: ≥ 26 mg/mL |
pKa | 2.97±0.12(Predicted) |
Storage Condition | −20°C |
Sensitive | Light Sensitive |
In vitro study | RG14620 inhibits colony formation (IC 50 =3 μM) and DNA synthesis (IC 50 =1 μM) by HER 14 cells, which are stimulated by 50 ng/mL EGF, in a dose-dependent manner. RG14620 also suppresses colony formation(IC 50 =4 μM) and DNA synthesis (IC 50 =1.25 μM) by EGF-stimulated MH-85 cells in a dose-dependent manner. The growth-inhibitory effect of RG14620 irreversible. |
In vivo study | RG14620, at a dose of 200 g/mouse/day inhibits H-85 tumor growth in nude mice. Mice show less cachexia and hypercalcemia, eat more food, and are more active than untreated MH-85 tumor-bearing animals. |
RG 14620,, 136831-49-7 - Risk and Safety
Safety Description | S22 - Do not breathe dust.
S24/25 - Avoid contact with skin and eyes.
|
WGK Germany | 3 |
RG 14620,, 136831-49-7 - Preparation solution concentration reference
| 1mg | 5mg | 10mg |
---|
1 mM | 3.635 ml | 18.173 ml | 36.346 ml |
5 mM | 0.727 ml | 3.635 ml | 7.269 ml |
10 mM | 0.363 ml | 1.817 ml | 3.635 ml |
5 mM | 0.073 ml | 0.363 ml | 0.727 ml |
Last Update:2024-01-02 23:10:35
RG 14620,, 136831-49-7 - Introduction
RG14620 is an organic compound with the chemical name 2-methyl -1, 3-pentanedione. Its structural formula is CH3C(O) CH2CH2CH22C (O)CH3.
RG14620 is a colorless liquid with a special fragrance. It is soluble in a variety of organic solvents, such as Alcohols, Ketones and ethers. At room temperature, RG14620 has low toxicity.
RG14620 has a wide range of uses in industry. It is an important raw material for synthetic resins, rubber and plastics, and can be used to produce coatings, glues, paints and packaging materials. In addition, RG14620 can also be used as a paint remover and cleaning agent, with the ability to remove paint and adhesives.
The preparation of RG14620 can be obtained by esterification of 1,5-adipic acid and methanol in the presence of an acidic catalyst. Mixing 1,5-adipic acid and methanol in an appropriate ratio, adding a small amount of acid catalyst, such as sulfuric acid or phosphoric acid, and controlling the reaction temperature within an appropriate range, RG14620 can be obtained.
Regarding the safety information of RG14620, its toxicity is low, but it is still necessary to pay attention to safe operation. Avoid contact with skin, eyes and mucous membranes during use. If contact occurs, rinse immediately with plenty of water and seek medical help. When storing and handling RG14620, appropriate protective measures should be taken, such as wearing gloves, goggles and protective clothing. In addition, the RG14620 should be kept away from open flames and high temperatures and avoid exposure to sunlight.
Last Update:2024-04-09 21:54:55